Metizolam Powder

Metizolam Powder

 

Consolidated Research Chemicals offer a wide range of designer drugs and bio-based chemicals to quality-driven and environmentally-conscious customers around the globe.

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Metizolam (also known as Desmethyletizolam) is a synthetic depressant of the thienodiazepine chemical class that reportedly produces etizolam-like effects such as anxiety suppression, disinhibition, sedation, muscle relaxation and memory suppression when administered. It is half as potent and has a 60% longer half-life than etizolam.

This compound was patented in 1995 by a Japanese company as a medication for treating anxiety. Despite this, it has little to no history of human usage prior to its release as a grey area research chemical by online vendors in September 2015.

Similar to benzodiazepines, the sudden discontinuation of thienodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.

It is highly recommended to taper one’s dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.

Thienzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors.

As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of metizolam on the nervous system.

Metizolam is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.4 hours. Metizolam acts as a full agonist at the benzodiazepine/GABAa receptor to produce its range of therapeutic and adverse effects.

Thienotriazolodiazepines are easily oxidized, rapidly metabolized, and have a lower risk of accumulation, even after prolonged treatment. Metizolam has a powerful anxiolytic action that is about 6 times greater than that of diazepam.

At higher dosages, metizolam allows for a reduction in time taken to fall asleep, an increase in total sleep time, and a reduction in the number of awakenings. Metzolam has also shown some similar characteristics to tricyclic antidepressants.

Although Metizolam has certain potential benefits such as anxiety suppression and muscle rest, it should be administered with caution and in small doses because of its harm and abuse potential. Metizolam can be life-threatening if administered with other depressants, including alcohol and opiates.

The harm potential due to long-term usage and toxicity dosage levels of Metizolam are not yet clear since the substance has not been adequately studied and analyzed in a scientific context. This is simply because of the lack of a known history of human usage.

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