Mescaline
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Mescaline (3,4,5-trimethoxyphenethylamine) is a psychedelic alkaloid of the phenethylamine class. It is mainly used as; a recreational drug, an entheogen, and a tool in use to supplement various types of practices for transcendence, including in meditation, psychonautics, and psychedelic psychotherapy, whether self administered or not.
It occurs naturally in the peyote cactus (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi) and the Peruvian Torch cactus (Echinopsis peruviana), and in a number of other members of the Cactaceae.
It is also found in small amounts in certain members of the Fabaceae (bean family), including Acacia berlandieri. Mescaline was first isolated and identified in 1897 by the German Arthur Heffter and first synthesized in 1919 by Ernst Späth.
The use of peyote in Native American religious ceremonies has been noted since the earliest European contact, notably by the Huichols in Mexico, but other cacti such as the San Pedro have been used in different regions, from Peru to Ecuador.
Dosage and effects
In traditional peyote preparations, the top of the cactus is cut from the roots, and dried to make disk-shaped buttons. It is chewed to produce its effect or soaked in water for an intoxicating drink.
However, the taste of the cactus is bitter, so users will often grind it into a powder and fill them in capsules to avoid having to taste it. The effective human dosage is 300–500 milligrams of pure mescaline, with the effects lasting for up to 12 hours.
Hallucinations occur at 300–600 mg, which is the equivalent to approximately 20 mescal buttons. Users typically experience visual hallucinations and radically altered states of consciousness, often experienced as pleasurable and illuminating but occasionally is accompanied by feelings of anxiety or revulsion.
Like most psychedelic hallucinogens, mescaline is not physically addictive. Mescaline-containing cacti can induce severe vomiting and nausea, which adds an important part to traditional Native-American or Shaman ceremonies as it is considered cleansing.
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