Scopolamine Powder

Scopolamine Powder

 

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Scopolamine, also known as hyoscine, or Devil’s Breath, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva.

When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It may also be used orally and as a transdermal patch since it has been long known to have transdermal bioavailability.

Scopolamine is in the antimuscarinic family of drugs and works by blocking some of the effects of acetylcholine within the nervous system.

Scopolamine was first written about in 1881 and started to be used for anesthesia around 1900. Scopolamine is also the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs, known as deliriants, due to their antimuscarinic-induced hallucinogenic effects in higher doses.

In these contexts, its mind-altering effects have been utilized for recreational and occult purposes.The name scopolamine is derived from one type of nightshade known as Scopolia, while the name “hyoscine” is derived from another type known as Hyoscyamus niger, or black henbane. It is on the World Health Organization’s List of Essential Medicines.

Medical uses:

Scopolamine has a number of formal uses in modern medicine where it is used in its isolated form and in low doses to treat:

Postoperative nausea and vomiting, Motion sickness, including sea sickness, leading to its use by scuba divers (where it is often applied as a transdermal patch behind the ear)

Gastrointestinal spasms, Kidney or liver spasms, Aid in gastrointestinal radiology and endoscopy, Irritable bowel syndrome, Clozapine-induced drooling, Bowel colic, Eye inflammation.

It is sometimes used as a premedication, especially to reduce respiratory tract secretions in surgery, most commonly by injection. Common side effects include sleepiness, blurred vision, dilated pupils, and dry mouth.

It is not recommended in people with angle-closure glaucoma or bowel obstruction. Whether its use during pregnancy is safe remains unclear, and use during breastfeeding is still cautioned by health professionals and manufacturers of the drug.

Scopolamine can be taken by mouth, subcutaneously, in the eye, and intravenously, as well as via a transdermal patch.

Breastfeeding:

Scopolamine enters breast milk by secretion. Although no human studies exist to document the safety of scopolamine while nursing, the manufacturer recommends that caution be taken if scopolamine is administered to a breastfeeding woman.

Overdose:

Physostigmine, a cholinergic drug that readily crosses the blood–brain barrier, has been used as an antidote to treat the central nervous system depression symptoms of a scopolamine overdose. Other than this supportive treatment, gastric lavage and induced emesis (vomiting) are usually recommended as treatments for oral overdoses.

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