Methylsulfonylmethane Powder

Methylsulfonylmethane Powder

Consolidated Research Chemicals offer a wide range of designer drugs and bio-based chemicals to quality-driven and environmentally-conscious customers around the globe.

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Dimethyl sulfone (DMSO2) is an organosulfur compound with the formula (CH3)2SO2. It is also known by several other names including methyl sulfone and (especially in alternative medicine) methylsulfonylmethane (MSM).

This colorless solid features the sulfonyl functional group and is the simplest of the sulfones. It is relatively inert chemically and is able to resist decomposition at elevated temperatures. It occurs naturally in some primitive plants, is present in small amounts in many foods and beverages, and is marketed (under the MSM name) as a dietary supplement.

It is sometimes used as a cutting agent for illicitly manufactured methamphetamine. It is also commonly found in the atmosphere above marine areas, where it is used as a carbon source by the airborne bacteria Afipia. Oxidation of dimethyl sulfoxide produces the sulfone, both under laboratory conditions and metabolically.

Use as a solvent:

Because of its polarity and thermal stability, molten DMSO2 has been used industrially as a high-temperature solvent. For example, displacement of aryl chlorides by potassium fluoride has been conducted in the liquid.
With a pKa of 31, the sulfone can be deprotonated with sodium amide. The conjugate base has been used as a nucleophile.

Medical and dietary use:

Methylsulfonylmethane is marketed as a dietary supplement with medical claims ranging from anti-inflammatory effects for pain management, skin condition and aging treatments, and immune system modulation.

No medical uses for MSM have been approved and there is limited evidence to support most of the claims. Small studies of MSM have suggested some benefit for treatment of oxidative stress and osteoarthritis, but evidence for other uses is lacking.

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