PB-22 Powder

PB-22 Powder

Consolidated Research Chemicals offer a wide range of designer drugs and bio-based chemicals to quality-driven and environmentally-conscious customers around the globe.

Consequently, Consolidated Research Chemicals stands for premium quality and service excellence. We supply life science, food, drugs, flavor, fragrance, personal care, extraction and industrial companies with mission-critical products since 30 years.

Subsequently, as a major dealer on Chemical & Allied Products, here is PB-22 Powder. We are a professional research chemical supplier in United Kingdom, we have sold research chemical products since 30 years. we supply good and professional service.

Conclusively, we recommend you buy PB-22 Powder.

PB-22 (QUPIC, SGT-21 or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered here as a cannabimimetic agent, and detected being sold in synthetic cannabis products in the United Kingdom in 2013.

PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs.

PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.

The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.

PB-22 was originally developed by New Zealand legal highs company Stargate International in 2012 as SGT-21, intended to be a structural hybrid of QMPSB and JWH-018.[5] However, no intellectual property protection was applied for and the compound quickly became subject to widespread grey-market sales outside the control of the inventors.

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